GeneralProperties of Ipamorelin and Its Use in Research

The study peptide Ipamorelin’s claims of promoting muscle cell development and proliferation have garnered considerable attention amongst the research community in recent years. Many researchers are thus interested in its properties and potential impacts.

Recently, anti-cell aging research has speculated that Ipamorelin may be an agent that may possibly down or even reverses the cycle of cell aging, enhance sleep quality, speed up metabolism, and support inflammatory issues. Below is a detailed overview of its possible properties to help researchers decide whether Ipamorelin is worth studying further.

 Ipamorelin Peptide: What is it?

Denmark’s Novo Nordisk pharmaceutical business created the growth hormone (GH) secretagogue Ipamorelin. To be more precise, Ipamorelin is a GH-releasing peptide that may function as a pentapeptide, a chain of five amino acids. Its effectiveness and potency in releasing GH have been suggested in animal experiments.

Ipamorelin Peptide: Mechanism of Action

The pituitary gland regulates the endocrine system’s natural hormone levels in animals by producing and distributing growth hormone (GH). A peptide known as Ipamorelin has been hypothesized to encourage the synthesis and release of endogenous GH.

The mechanism of action of Iamorelin is believed to be similar to that of the naturally occurring hormone ghrelin, secreted by the enteroendocrine cells in the intestines. Because of this, Ipamorelin is sometimes called a “ghrelin mimetic.” Like endogenous ghrelin, it is speculated to stimulate pituitary cells to secrete more GH by binding specifically to the same GHSR-1a receptors. Several anabolic processes in the body are believed to be subsequently affected by this, including:

  • Power consumption
  • Fat oxidation
  • Suppression of hunger hormone release

Compared to natural growth hormone-releasing hormone (GHRH), Ipamorelin’s stimulation of GH release is believed to be equivalent, making it the first growth hormone-releasing peptide (GHRP) receptor agonist.

Investigations purport that Ipamorelin may control the secretion of somatostatin, a GHIH that blocks the organism’s natural growth hormone production. Because Ipamorelin has been hypothesized to reduce somatostatin levels, the organism’s GH levels may be naturally stimulated to rise.

Ipamorelin Peptide and Diabetes

As suggested by some studies, because of its potential to increase the production of growth hormone (GH) and to imitate ghrelin, Ipamorelin may have promise in the context of some disorders. For instance, Ipamorelin may positively affect organisms since it is believed to reverse the glucocorticoid-induced reduction in bone production in adult rats.

Multiple studies have assessed Ipamorelin’s potential to increase gastric motility and speed up gastric emptying. Ipamorelin has been indicated to hasten stomach emptying in adult male rats with induced postoperative ileus (POI) in a 2012 research by Greenwood-Van Meerveld et al. These results suggest it might have the potential to be a useful agent in research within the context of delayed stomach emptying, a prevalent issue under scientific investigation.

Beck et al. performed a mini-randomized, placebo-controlled study in 2014 to see whether Ipamorelin may help postoperative nausea and vomiting (POI) after colon resection. The experiment included many centers and was designed to be double-blinded. When comparing Ipamorelin versus placebo, the “clinical endpoints did not reach statistical significance,” ruling the trial’s discontinuation.

Ipamorelin Peptide and Ghrelin

In many animal investigations, it has been purported that Ipamorelin may boost GH release. Findings imply that Ipamorelin may stimulate pituitary cell GH secretion in rats and pigs “with a potency and efficacy similar to GHRP-6,” according to K. Raun et al. In 2002, the European Journal of Anatomy reported that female rats might have their GH secretion stimulated by Ipamorelin. Researchers speculated that giving Ipamorelin to rats may cause an increase in GH production and distribution.

Ipamorelin Peptide and Body Mass Index

Ipamorelin has been indicated to cause animals to gain weight. Researchers speculated that after 9 weeks of being presented with Ipamorelin twice daily, female GH-deficient mice suggested a 15.3% rise, compared to a 16.9% increase in non-GH-deficient animals. The findings implied that the size of the two groups of mice that received growth hormone (GH) was 95.5% and 27.5% larger, respectively. In contrast to GH, Ipamorelin did not appear to have caused any weight gain in the rodent’s dissected organs, which caused the liver to enlarge.

Ipamorelin Peptide and Weight

A review of the existing investigations shows data of a correlation between Ipamorelin exposure and fat reduction in research models, which is presently lacking. Additionally, minimal data indicates that it may have this effect on animals. For example, Ipamorelin was speculated to increase total body fat percentages in GH-intact mice, as suggested by a 9-week animal research by Lall et al. that compared GH-deficient and non-GH-deficient mice.

Regardless, Ipamorelin’s potential to elevate HGH levels has scientists scouring it for clues about its impacts on body composition. Studies have purported that using growth hormone supplements may induce muscle cell proliferation in research models, and these studies have not included Ipamorelin.

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[i] Raun, K, Hansen, B., Johansen, N., Thogersen, H, Madsen, K, Ankersen, M, & Andersen, P. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology. 139 (5): 552–561.

[ii] Florini, J. R. (1987). Hormonal control of muscle growth. Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine, 10(7), 577-598.

[iii] Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev. 2005 Apr;85(2):495-522. doi: 10.1152/physrev.00012.2004. PMID: 15788704.

[iv] Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 2001 Dec;86(12):5992. doi: 10.1210/jcem.86.12.8111. PMID: 11739476.

[v] Anderson, N.B., Malmlof, K., Johansen, P.B., Andreassen., T.T., Ortoft, G., & Oxlund, H. (2001). The Growth Hormone Secreatgoge Ipamorelin Counteracts Glucocrticoid-Induced Decrease in Bone Formation of Adult Rats. Growth Hormone & IGF Research. 11(5): 266-272.

[vi] Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C. Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus. J Exp Pharmacol. 2012 Oct 19;4:149-55. doi: 10.2147/JEP.S35396. PMID: 27186127; PMCID: PMC4863553.

[vii] Beck DE, Sweeney WB, McCarter MD; Ipamorelin 201 Study Group. Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. Int J Colorectal Dis. 2014 Dec;29(12):1527-34. doi: 10.1007/s00384-014-2030-8. Epub 2014 Oct 21. PMID: 25331030.

[viii] Lall S, Tung LY, Ohlsson C, Jansson JO, Dickson SL. Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues. Biochem Biophys Res Commun. 2001 Jan 12;280(1):132-8. doi: 10.1006/bbrc.2000.4065. PMID: 11162489.

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