Muscle size regulation is an essential aspect of good health—skeletal muscle atrophy results in decreased strength, lower quality of life, and metabolic problems. As a result, treatments to reduce muscle wasting and promote muscle growth during various (pathological) physiological states such as sarcopenia, immobility, malnutrition, and cachexia are required to address this widespread health problem. The effects of Urolithin Powder, an ellagitannin-derived metabolite, on skeletal muscle growth were investigated to enhance muscle growth. To find out more, keep reading!
What is Urolithin A & B?
Urolithin A is a naturally occurring metabolite produced by human gut bacteria when consuming ellagitannins or ellagic acid-containing meals or supplements. Urolithin A 99 is a beige to yellow powder with a CAS number of 1143-70-0 used for anti-aging and muscular strength.
Urolithin B, a phenolic chemical generated from pomegranate peels, is discovered in the human gut after eating ellagitannin-rich food, including pomegranate extract, strawberries, walnuts, and oak-aged red wine.Its CAS number is 1139-83-9.
What Is Urolithin A’s Mechanism Of Action?
Urolithin A precursors include ellagic acids and ellagitannins. Ellagitannins are hydrolyzed in the colon to liberate Ellagic acid, which is then processed by the gut microbiota into Urolithins by removing the hydroxyl group from one of its two lactones. It has a molecular formula of C13H803 Urolithin A powder enters the flow system of the gut after it is eaten in the intestine.
Urolithin A doesn’t come from food sources directly. It is metabolized from other compounds including 8-Methyl Ether that further breakdown into Urolithin A .
According to Wikipedia, mitophagy is a (selective breakdown of your food by mitochondria). It frequently occurs in faulty mitochondria as a result of damage or stress. On the other hand, the mitophagy function gets less efficient as we age. Fortunately, Urolithin A has been found to enhance mitophagy species-specific.
Package Information Of the Supplement
It’s IUPAC name is 3,8 Dihydroxybenzo[c]chromen-6-one.The molecular formula of supplement is C13H804 with molecular weight of 228.2. It is available in light yellow powder solid form with the melting point of >300°C.
What Is Urolithin B’s Mechanism Of Action?
According to studies, Urolithin B has been demonstrated to activate AMPK, which increases fat burning and energy expenditure while declining inflammation and oxidative stress.
Urolithin B has been demonstrated to improve C2C12 myotube growth by increasing protein synthesis and inhibiting the ubiquitination-proteasome pathway. More genetic research suggests that this happens due to an interaction with the androgen receptor.
The exact mechanism by which Urolithin B interacts with AMPK is unknown; however, it appears that there is some form of cross-talk between our old pal mTOR (mammalian target of rapamycin) and its close buddy AMPK.
Package Information Of Supplement
It’s IUPAC name is 3-Hydroxy-6H-dibenzo[b,d]pyran-6-one.The molecular formula of supplement is C13H803 with molecular weight of 212.2g/mol. It is available in light brown powder solid form with the melting point of >300°C. The storage condition is 2-8°C.
Amazentis- Urolithin A Best Muscle Building Supplements
A life sciences business has commercialized a new component that improves cellular activities and muscle strength. Timeline Mitopure – a very pure version of Urolithin that has been shown to help fight age-related cellular decline and boost muscular strength- is included in cellular nutrition backed by a decade-long study. With the world’s aged population growing, customers are looking for ways to retain muscle strength, mobility, and increased quality of their old lives.
According to Business, many people begin to lose muscle power in their 40s due to an age-related decrease in cellular bioenergetics and mitochondrial function.
Ep1logue – Urolithin B Best Muscle Building Supplements
Ep1logue from Olympus Labs is a joint Urolithin B supplement Ep1logue is a natural supplement that aids in developing lean muscle while also avoiding muscle breakdown. It is one of the essential natural muscle builders on the market, boosting protein synthesis for muscle growth and recovery.
The trademarked ingredient “uroblin” is 99% pure Urolithin B derived from Punica granatum (pomegranate). It’s a muscle booster that also acts to slow down your body’s muscular breakdown!
Epicatechin, in the form of PhytoFuse, is used to provide you with the energy you need to get through a challenging workout and recover swiftly. Gallate-Enhanced Oligomers like Vaso6 will help you feel more formed during strenuous activity, so go ahead and push yourself!
Dosage Of Urolithin
- According to clinical trial data, the most excellent alternative for boosting muscular enhancement and anti-aging advantages is to take 500mg Urolithin A and 99% daily for four months; according to Wikipedia, a serving size of 250mg to 1000mg of Urolithin A is considered safe.
- For the time being, there are no Urolithin B supplements available separately, and Urolithin B is frequently combined with other muscle-building ingredients like epicatechin and phosphatidylcholine. A popular starting dose is 300mg of Urolithin B per day.
Side Effects Of Urolithin
There have been no recorded side effects as of yet. The FDA has classified Urolithin A and its variants as generally recognized as safe with no reported adverse effect to date. More clinical trials on Urolithin B should be conducted in the future to provide a more thorough evaluation of the characteristics that are now unavailable due to the scarcity of research.
Wrapping Up
It’s possible that evaluating Urolithins in people will be more difficult. Even though these metabolites are formed in the human gut, these metabolites are not found in meals (at least in significant concentrations). So, it’s better to take them along with your diet to make your muscles strong.
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